Table 2.
Thickness in millimeters and percentage of λ-carrageenan 1% paw edema inhibition in BALB/c mice treated with ethyl acetate fraction of Euterpe oleraceae.
| Treatment | λ-Carragenan | Dose (mg/kg) |
Administration Time (% Edema Inhibition) | |||
|---|---|---|---|---|---|---|
| 1 h | 2 h | 3 h | 4 h | |||
| PBS | - | - | 0.04 ± 0.055 | 0.02 ± 0.045 | 0.02 ± 0.045 | – 1 |
| + | - | 0.22 ± 0.084 | 0.32 ± 0.134 | 0.48 ± 0.084 | 0.56 ± 0.055 | |
| EO-ACET | + | 250 | 0.20 ± 0.100 | 0.25 ± 0.129 | 0.36 ± 0.089 (25.00) | 0.46 ± 0.089 (17.85) |
| + | 500 | 0.22 ± 0.096 | 0.25 ± 0.058 | 0.34 ± 0.114 (29.16) | 0.36 ± 0.114 (35.71) * | |
| + | 1000 | 0.20 ± 0.100 | 0.25 ± 0.058 | 0.32 ± 0.084 (33.33) | 0.34 ± 0.055 (39.29) ** | |
| Dexamethanose | + | 5 | 0.18 ± 0.084 | 0.20 ± 0.100 | 0.20 ± 0.071 (58.33) **** | 0.20 ± 0.071 (64.28) **** |
Data represent the mean ± standard deviation of the experiment performed in quintuplicate. 1 There was no edema thickness in this group at this evaluation time. * p < 0.05; ** p < 0.01; **** p < 0.0001, after analysis of variance (two-way ANOVA) followed by Bonferroni’s multiple comparisons test when compared to the PBS group. EO-ACET: Euterpe oleracea ethyl acetate fraction. +: λ-carrageenan inoculation; -: PBS administration.