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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Trends Pharmacol Sci. 2021 Apr 16;42(6):448–460. doi: 10.1016/j.tips.2021.03.002

Table1:

List of the highly effective lipids and polymers for RNA delivery

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*

The ED50 value is the dose of siRNA for 50% FVII gene silencing in mice with optimized LNPs formulation

**

The exact value of Lipid 503O13 and Lipid 10 have not been reported, however the measured value of pKa reported to be in between the given value.