Fig 4. Inflammation and tissue pathology are reduced in the descending colon following treatment.

Inflammation of formaldehyde-fixed, paraffin-embedded tissues was assessed via immunohistochemistry (IHC) and H&E. After the clean-up regimen, descending colon biopsies showed substantial reduction in several inflammatory pathways, including neutrophil recruitment (MPO; A), interferon signaling (Mx-1; B), cytokine signaling (pSTAT1; C), and overall pathology (D). IHC quantification was performed using HALO and pathology quantification occurred via independent scoring by two pathologists. The dotted line in panel D marks the minimum pathology score available, which is 3.