Fig 6. Reduction in inflammatory signaling pathways in the liver following multimodal therapy.

Formaldehyde-fixed, paraffin-embedded tissues were assessed for Mx1, an interferon-induced GTPase, via immunohistochemistry (IHC). (A) Animals with known enteric pathogens had a larger range of liver Mx1 expression before treatment and significant reduction following the short course multimodal treatment. (B) Representative images of Mx1-stained pre-treatment sections of liver (left-hand column) exhibited higher focal staining within tissue parenchyma, as well as increased staining within cells residing in the sinusoids. Treatment (right-hand column) led to a substantial reduction in Mx1 within both of these tissue compartments (i.e. tissue parenchyma and sinusoid).