Fig 7. Inflammation and immune activation at GI-tract draining sites are reduced following short course multimodal therapy.

Flow cytometric analysis was performed on B cells, CD4+ T cells, DCs, and MOs derived from mesenteric lymphoid tissue, before and after multimodal treatment. Subsets were summed for overall responses with the figure showing the mean (+ SEM) of these overall responses both pre- and post-treatment. A reduction in both CD14+ CD16+ and CD14- CD16+ monocytes was observed, as well as a decreased SEM for CD169+ expression by all HLA-DR+ cells (A). A reduction of the proliferation marker Ki67 and reduced SEM post-treatment in CD4+ T cells (B) and B cells (C) was exhibited. B cells were defined by their CD20 positivity followed by their expressions of CD27 and IgD. T cell and innate subsets were defined as described in Fig 5.