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. 2021 May 13;17(5):e1008859. doi: 10.1371/journal.pcbi.1008859

Fig 1. Flowchart of the semantics-based automated model composition method.

Fig 1

The left column illustrates the general approach in the integration of bond graph models in CellML using SemGen, and the right column shows the same procedure specific to the ADAN circulation model. In both approaches, the bond graph models are created based on template models (1), and annotated using the SemGen Annotator (2). Later, depending on whether the system has similar larger compartments or any symmetry, the SemGen merger tool joins the modules in a number of steps (3). The amounts for the symbolic model parameters are allocated from a CellML file containing the annotated parameters and their values (4). In stage (3): HN: Head and Neck, H: Heart, RA: Right Arm, LA: Left Arm, T: Trunk, RL: Right Leg, LL: Left Leg.