Table 1.
Baseline characteristics of PE patients who received CDT versus conservative therapy before propensity matching
| CDT (N = 87) | Conservative treatment (N = 1007) | p value | |
|---|---|---|---|
| Gender | 0.92 | ||
| Female, n (%) | 50 (57%) | 584 (58%) | |
| Male, n (%) | 37 (43%) | 423 (42%) | |
| Race | 0.03 | ||
| Black/African-American, n (%) | 71 (82%) | 690 (69%) | |
| White, n (%) | 12 (14%) | 267 (27%) | |
| Other, n (%) | 4 (4.6%) | 50 (5.0%) | |
| Age | 57 (42, 71) | 61 (47, 71) | 0.40 |
| Hours hospitalized prior to PE diagnosis | 17 (5.9, 30) | 21 (14, 73) | < 0.001 |
| Body mass index | 32 (26, 39) | 28 (24, 34) | < 0.001 |
| NT-proBNP | 1,949 (830, 3,970) | 664 (96, 2,678) | < 0.001 |
| Troponin (high) | 3 (0.06, 3) | 0.04 (0.03, 3) | < 0.001 |
| NT-proBNP > 500, n (%) | 44 (51%) | 157 (16%) | < 0.001 |
| No NT-proBNP > 500 | 7 (8.1%) | 127 (13%) | |
| No NT-proBNP measured | 36 (41%) | 723 (72%) | |
| Troponin ≥ 0.03, n (%) | 38 (44%) | 160 (16%) | < 0.001 |
| No troponin ≥ 0.03 | 30 (34%) | 397 (39%) | |
| No troponin measured | 19 (22%) | 450 (45%) | |
| RV dysfunction by echocardiography or CT | 76 (87%) | 303 (30%) | < 0.001 |
| No RV dysfunction | 11 (13%) | 704 (70%) | |
| On ventilator (before PE diagnosis) | 13 (15%) | 69 (6.9%) | 0.006 |
| Location at PE diagnosis | < 0.001 | ||
| Ward | 17 (20%) | 553 (55%) | |
| Intensive care unit | 43 (50%) | 214 (21%) | |
| Emergency Department | 26 (30%) | 240 (24%) | |
| Hemoglobin (baseline) | 12.7 (10.4, 14.1) | 10.8 (9.3, 12.6) | < 0.001 |
| Creatinine (baseline) | 1.0 (0.8, 1.3) | 0.9 (0.7, 1.1) | < 0.001 |
| CDT (N = 87) | Conservative treatment (N = 1007) | p value | |
|---|---|---|---|
| Systolic blood pressure (lowest) | 99 (86, 118) | 107 (96, 119) | < 0.001 |
| Diastolic blood pressure (lowest) | 61 (48, 71) | 61 (52, 69) | 0.81 |
| Heart rate (highest) | 112 (100, 127) | 110 (95, 124) | 0.32 |
| Respirations (highest) | 28 (23, 31) | 24 (20, 29) | < 0.001 |
| Oxygen flow (L/min) (highest) | 3 (0, 6) | 2 (0, 3) | < 0.001 |
| Oxygen saturation (lowest) | 91 (85, 93) | 93 (90, 95) | < 0.001 |
| Temperature (highest) | 98.2 (97.5, 99.0) | 98.4 (97.7, 99.3) | 0.02 |
| Heart rate ≥ 90 n(%) | 78 (90%) | 858 (85%) | 0.26 |
| Systolic BP ≤ 90 n(%) | 24 (28%) | 153 (15%) | 0.003 |
| On supplemental oxygen n(%) | 61 (70%) | 601 (60%) | 0.04 |
Unless otherwise indicated, laboratory and VS values are medians and (x, x) represents IQR, where the value represents the 25th and 75th quartiles respectively. Otherwise, parentheses indicate % of patients
CDT catheter-directed therapy, PE pulmonary embolism, SMD standardized mean difference, ICU intensive care unit