Table 2. Organ-specific nucleotide metabolases in tumors.
Tumor/cell type | Kinase | Signaling axis | Enzymes |
Gastric cancer | UHMK1 | NCOA3/ATF4 | ATIC, IMPDH |
Cholangiocarcinoma | CLK3 | USP13/Fbxl14/c-Myc | ATIC |
Hepatocellular carcinoma | Dyrk3 | NCOA3/ATF4 | PPAT |
Glioblastoma-initiating cells | DHODH |