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. 2021 May 5;13(9):13349–13358. doi: 10.18632/aging.202962

Table 2. Organ-specific nucleotide metabolases in tumors.

Tumor/cell type Kinase Signaling axis Enzymes
Gastric cancer UHMK1 NCOA3/ATF4 ATIC, IMPDH
Cholangiocarcinoma CLK3 USP13/Fbxl14/c-Myc ATIC
Hepatocellular carcinoma Dyrk3 NCOA3/ATF4 PPAT
Glioblastoma-initiating cells DHODH