Table 1. Clinical and demographic data of the ZJU database.

Group	YHC	EOAD	OHC	LOAD	Interaction		ANOVA
	n=64	n=31	n=46	n=45	F/χ2	p	F/χ2	p
Age	59.7 (2.5)	60.8 (3.3)	72.4 (3.8)	74.3 (4.6)	0.7	0.4	86.9	<0.001
Education	10.7 (3.7)	9.4 (2.9)	10.5 (4.1)	10.5 (4.0)	2.6	0.1	0.9	0.4
Sex, F/M	38/26	21/10	22/24	23/22	0.1	0.8	3.7	0.3
GDS	1.9 (2.5)	1.6 (1.5)	1.2 (1.6)	1.4 (1.2)	0.7	0.4	1.2	0.3
CDR global	0 (0)	1.1 (0.3)ƚ	0 (0)	1.0 (0.5)ǂ	0.2	0.6	220.9	<0.001
CDR sum	0 (0)	4.9 (2.1)ƚ	0 (0.1)	4.7 (3.6)ǂ	0.1	0.7	87	<0.001
MMSE	28.1 (1.6)	20.6 (3.6)ƚ	28.3 (1.5)	20.0 (3.7)ǂ	0.7	0.4	140	<0.001
LM delay	8.5 (4.3)	0.6 (1.3)ƚ	8.6 (3.7)	0.3 (0.7)ǂ	0.01	0.9	96	<0.001
TMT-A	69.2 (28.2)	98.3 (40.6)ƚ	70.8 (29.8)	106.3 (38.0)ǂ	0.4	0.6	16.5	<0.001
TMT-B	172.6 (64.3)	223.6 (90.6)ƚ	181.5 (69.8)	250.3 (83.4)ǂ	0.1	0.7	17.8	<0.001
SVF	16.3 (3.9)	11.0 (5.3)ƚ	16.0 (4.8)	8.9 (5.0)ǂ	3.6	0.1	31.3	<0.001
CDT	4.1 (0.7)	3.2 (0.6)ƚ	4.3 (0.6)	3.3 (0.6)ǂ	0.2	0.7	33.6	<0.001

ƚ and ǂ Represent the significant difference between YHC and OHC, as well as EOAD and LOAD (p<0.05), respectively. Interactive effects comprise the factors of onset age (<65 or ≥65 years) and disease status (controls or patients). Abbreviations: YHC, young healthy controls; EOAD, early-onset Alzheimer's disease; OHC, old healthy controls; LOAD, late-onset Alzheimer's disease; CDR global/sum, Clinical Dementia Rating, global score and sum score of box; MMSE, Mini-Mental State Examination; GDS, Geriatric Depression Scale; LM, Logical Memory; TMT-A/B, Trail Making Test, part A/B; SVF, Semantic Verbal Fluency.