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. 2021 May 7;9(5):522. doi: 10.3390/biomedicines9050522

Figure 2.

Figure 2

Fission/fusion machinery in BD patients’ fibroblasts. The levels of the mitochondrial fission proteins (A) Fis1 and (B) p-Drp1 and the mitochondrial fusion proteins (C) OPA1 (D) Mfn2 and (E) Mfn1, in fibroblasts from BD patients and control individuals were evaluated by Western blot analysis. Drp1 was used as the loading control for p-Drp1 (S616) and β-actin was used as loading control for the other proteins. The results were normalized to β-actin or Drp1 and expressed as mean ± SEM of 5 different control individuals and 3-4 BD patients. WB representative images correspond to BD and control samples analyzed on the same gel. * p < 0.05, significantly different from control group, as determined by Mann–Whitney non-parametric test.