TABLE 2:
1H-MR spectroscopy findings in patients with late-onset GM2G
| Patient | Thalamus |
White Matter |
Cerebellum |
||||||
|---|---|---|---|---|---|---|---|---|---|
| NAA | Cr | Cho | NAA | Cr | Cho | NAA | Cr | Cho | |
| 1 | 6.16 | 3.35 | 1.06 | 4.47 | 2.49 | 0.75 | 4.25 | 3.65 | 1.30 |
| 2 | 6.35 | 3.72 | 1.26 | 5.38 | 3.69 | 1.14 | 3.77 | 1.54 | 0.66 |
| 3 | 6.20 | 3.09 | 0.95 | 4.75 | 2.49 | 0.81 | 5.54 | 2.14 | 0.78 |
| 4 | 7.73 | 4.20 | 1.16 | 7.76 | 4.81 | 1.01 | N/A | N/A | N/A |
| 5 | 10.13 | 5.36 | 1.45 | 8.67 | 6.17 | 1.93 | 6.35 | 4.96 | 1.93 |
| 6 | 8.10 | 4.37 | 1.43 | 8.76 | 5.31 | 1.89 | 9.38 | 7.06 | 2.45 |
| 7 | 4.58 | 2.69 | 0.71 | 3.43 | 2.14 | 0.57 | 2.57 | 1.30 | 0.43 |
| 8 | 5.40 | 3.93 | 0.74 | 5.25 | 3.58 | 0.47 | 1.33 | 1.27 | 0.52 |
| 9 | 3.77 | 2.56 | 0.71 | 3.29 | 2.65 | 0.69 | 1.37 | 0.92 | 0.32 |
| Patients 1–9 | 6.50 ± 1.9 | 3.69 ± 0.8 | 1.03 ± 0.3 | 5.75 ± 2.1 | 3.70 ± 1.4 | 1.05 ± 0.5 | 4.3 ± 2.7 | 2.9 ± 2.2 | 1.05 ± 0.8 |
| Controls (n = 8) | 11.0 ± 2.7 | 5.43 ± 1.2 | 1.43 ± 0.4 | 9.92 ± 2.7 | 5.20 ± 1.6 | 1.40 ± 0.4 | 11.1 ± 1.1 | 8.7 ± 1.3 | 2.4 ± 0.3 |
Concentrations of the 3 metabolites are in millimolars. Bold entries (for patients) are significantly different from the controls (P = .005).