Table 2.
Comparison of MPN-10 baseline symptom items and total score for PV patients by cohort.
| MPN-SAF Survey Item | Cyto PV cohort (N = 224) |
MPN-SAF cohort (N = 645) |
Total (N = 869) |
p Value (adjusted) | ||
|---|---|---|---|---|---|---|
| Mean (SD) | Adjusted mean (std err)a | Mean (SD) | Adjusted mean (std err)a | Mean (SD) | ||
| WORST fatigue (BFI) | 3.1 (2.8) | 3.1 (0.21) | 3.9 (2.9) | 3.9 (0.11) | 3.7 (2.9) | .004b |
| Early satiety | 2.0 (2.7) | 2.0 (0.33) | 2.2 (2.7) | 2.2 (0.11) | 2.2 (2.7) | NS |
| Abdominal discomfort | 1.6 (2.1) | 1.7 (0.28) | 1.5 (2.3) | 1.5 (0.09) | 1.6 (2.2) | NS |
| Inactivity | 1.6 (2.4) | 1.8 (0.33) | 2.1 (2.7) | 2.1 (0.11) | 2.1 (2.6) | NS |
| Concentration | 2.0 (2.6) | 2.0 (0.33) | 2.2 (2.6) | 2.2 (0.11) | 2.2 (2.6) | NS |
| Night sweats | 1.8 (2.7) | 2.1 (0.34) | 1.9 (2.7) | 1.9 (0.11) | 1.9 (2.7) | NS |
| Itching | 2.7 (3.2) | 2.8 (0.38) | 2.5 (3.0) | 2.5 (0.12) | 2.6 (3.0) | NS |
| Bone pain | 1.9 (2.9) | 1.9 (0.35) | 2.0 (2.8) | 2.0 (0.11) | 2.0 (2.8) | NS |
| Fever | 0.4 (1.1) | 0.4 (0.14) | 0.4 (1.1) | 0.4 (0.05) | 0.4 (1.1) | NS |
| Weight loss | 0.7 (1.5) | 0.8 (0.26) | 1.1 (2.2) | 1.1 (0.08) | 1.1 (2.1) | NS |
| MPN-SAF TSS | 18.3 (15.7) | 19.4 (2.0) | 19.9 (16.3) | 19.9 (0.64) | 19.7 (16.2) | NS |
a
Adjusted mean values estimated from multiple regression model which included the following covariates: age, baseline hematocrit, platelets, PV risk category, cohort, and interaction effect of hematocrit and cohort.
b
Anova F-test.