Table 1.
Demographics and clinical characteristics of MF patients with and without thrombocytopenia.
| Normal (Plt > 100 × 109/L) | Thrombocytopenia (Plt < 100 × 109/L) | Total | p-value | |
|---|---|---|---|---|
| n = 329 | n = 89 | n = 418 | ||
| Age (mean, SD) | 61.0 (12.15) | 57.4 (12.67) | 60.2 (12.34) | 0.01 |
| Gender (male) | 156 (47.4%) | 42 (47.2%) | 198 (47.4%) | 0.97 |
| MF subtype | 0.01 | |||
| Primary MF | 217 (66%) | 73 (82%) | 290 (69.4%) | |
| ET-MF | 64 (19.5%) | 7 (7.9%) | 71 (17%) | |
| PV-MF | 48 (14.6%) | 9 (10.1%) | 57 (13.6%) | |
| DIPSS risk | 0.07 | |||
| Low | 38 (19.3%) | 5 (13.9%) | 43 (18.5%) | |
| Intermediate-1 | 113 (57.4%) | 15 (41.7%) | 128 (54.9%) | |
| Intermediate-2 | 41 (20.8%) | 14 (38.9%) | 55 (23.6%) | |
| High | 5 (2.5%) | 2 (5.6%) | 7 (3%) | |
| Anemia (Hgb < 11 g/dL) | 147 (44.8%) | 68 (76.4%) | 215 (51.6%) | < 0.001 |
| Leukopenia (WBC < 3.5 × 109/L) | 35 (10.6%) | 26 (29.2%) | 61 (14.6%) | < 0.001 |
| Lab abnormality | 172 (52.3%) | 89 (100%) | 261 (62.4%) | < 0.001 |
| Prior thrombosis | 42 (12.9%) | 5 (5.6%) | 47 (11.3%) | 0.06 |
| Prior hemorrhage | 14 (4.3%) | 7 (7.9%) | 21 (5.1%) | 0.17 |
| Required RBC transfusion | 62 (19.1%) | 31 (34.8%) | 93 (22.5%) | 0.002 |
| Mean MPN duration (years, SD) | 8.8 (8.33) | 11.9 (10.86) | 9.3 (8.81) | 0.049 |
DIPSS, Dynamic International Prognostic Scoring System; ET, essential thrombocythemia; Hgb, hemoglobin; MF, myelofibrosis; Plt, platelets; PV, polycythemia vera; RBC, red blood cell; SD, standard deviation; WBC, white blood cell.