Table 2.
Demographics and clinical characteristics of MF patients with moderate and severe thrombocytopenia.
| Moderate Thrombocytopenia (Plt 51–100 × 109/L) | Severe Thrombocytopenia (Plt < 50 × 109/L) | Total | p-value | |
|---|---|---|---|---|
| n = 46 | n = 43 | n = 89 | ||
| Age (mean, SD) | 57.9 (11.29) | 56.9 (14.11) | 57.4 (12.67) | 0.72 |
| Gender (male) | 21 (45.7%) | 21 (48.8%) | 42 (47.2%) | 0.76 |
| MF subtype | 0.87 | |||
| Primary MF | 38 (82.6%) | 35 (81.4%) | 73 (82%) | |
| ET-MF | 4 (8.7%) | 3 (7%) | 7 (7.9%) | |
| PV-MF | 4 (8.7%) | 5 (11.6%) | 9 (10.1%) | |
| DIPSS risk | 0.09 | |||
| Low | 4 (21.1%) | 1 (5.9%) | 5 (13.9%) | |
| Intermediate-1 | 10 (52.6%) | 5 (29.4%) | 15 (41.7%) | |
| Intermediate-2 | 5 (26.3%) | 9 (52.9%) | 14 (38.9%) | |
| High | 0 (0%) | 2 (11.8%) | 2 (5.6%) | |
| Anemia (Hgb < 11 g/dL) | 31 (67.4%) | 37 (86.0%) | 68 (76.4%) | 0.04 |
| Leukopenia (WBC < 3.5 × 109/L) | 9 (19.6%) | 17 (39.5%) | 26 (29.2%) | 0.04 |
| Lab abnormality | 46 (100%) | 43 (100%) | 89 (100%) | |
| Prior thrombosis | 2 (4.3%) | 3 (7%) | 5 (5.6%) | 0.59 |
| Prior hemorrhage | 2 (4.3%) | 5 (11.6%) | 7 (7.9%) | 0.20 |
| Required RBC transfusion | 9 (19.6%) | 22 (51.2%) | 31 (34.8%) | 0.002 |
| Mean MPN duration (years, SD) | 12.3 (12.52) | 11.5 (8.58) | 11.9 (10.86) | 0.83 |
DIPSS, Dynamic International Prognostic Scoring System; ET, essential thrombocythemia; Hgb, hemoglobin; MF, myelofibrosis; Plt, platelet; PV, polycythemia vera; RBC, red blood cell; SD, standard deviation; WBC, white blood cell.