Table 3.
Baseline MPN-SAD symptom scores*.
| Leadin (N = 21) |
Severe Subset† (n = 14) |
|||
|---|---|---|---|---|
| Mean | Median | Mean | Median | |
| Bone pain | 1.87 | 1.00 | 2.71 | 2.36 |
| Problems with concentration | 2.52 | 1.86 | 3.36 | 3.29 |
| Abdominal discomfort | 3.65 | 2.86 | 4.73 | 5.00 |
| Fatigue | 4.34 | 4.86 | 5.84 | 5.64 |
| Fever (> 37.8 °C) | 0.37 | 0.00 | 0.56 | 0.00 |
| Early satiety | 3.69 | 3.86 | 4.74 | 4.93 |
| Inactivity | 3.45 | 3.29 | 4.76 | 5.07 |
| Pruritus | 1.51 | 0.86 | 1.83 | 1.14 |
| Night sweats | 1.95 | 1.14 | 2.79 | 3.36 |
| Unintentional weight loss | 0.66 | 0.14 | 0.83 | 0.36 |
| Spleen-related symptom score‡ | 7.33 | 6.86 | 9.48 | 9.86 |
| Constitutional symptom score§ | 9.67 | 7.71 | 13.16 | 14.07 |
| Total symptom score | 24.00 | 24.86 | 32.14 | 30.36 |
| nTssǁ | 17.00 | 17.43 | 22.64 | 22.00 |
MPN-SAD = Myeloproliferative Neoplasm Symptom Assessment Diary; nTSS = new total symptom score.
*
Large values correspond to worse symptoms.
†
Severe Subset included patients with a baseline (7-day average) MPN-SAD severity score ≥ 5 (on 0–10 scale) on at least one, or a severity score ≥3 on at least two of the following items: fatigue, early satiety, abdominal discomfort, inactivity, night sweats, pruritus, and/or bone pain.
‡
Spleen-related symptom score is the sum of early satiety and abdominal discomfort.
§
Constitutional symptom score is the sum of fatigue, night sweats, pruritus, and bone pain.
ǁ
nTSS is the sum of spleen-related symptoms and constitutional symptoms.