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. Author manuscript; available in PMC: 2022 Mar 24.
Published in final edited form as: Chem Rev. 2021 Jan 28;121(6):3271–3296. doi: 10.1021/acs.chemrev.0c00967

Table 1.

NRTI Resistance Mutations

NRTI resistance mutation(s) mechanism of resistance drug(s) affected by resistance mutation(s)
K65R discrimination TFV, ABC, ddI, and d4T
Y115F discrimination ABC
L74V discrimination ddI
M184V/I discrimination FTC and 3TC
Q151M discrimination ddI, AZT, d4T, and ABC
Q151M/A62V/V75I/F116Y discrimination ddI, AZT, d4T, and ABC
Type 1: M41L/L210W/T215Y excision AZT and d4T
Type 2: D67N/K70R/T215Y/K219Q excision AZT and d4T