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Fold-Changes of NNRTI Resistance compared to WT EC50s
| resistance mutation | NVP | ETR | EFV | RPV | DOR | ref |
|---|---|---|---|---|---|---|
| L100I | 7.3 | 1.3 | 20.3 | 0.9 | <3 | 218–220 |
| K101E | NA | 2.7 | 3.8 | 2.4 | 4.5 | 110,219 |
| K103N | 81 | 0.9 | 32.5 | 0.9 | 1 | 218–220 |
| V106A | >42 | 0.5 | 2.0 | 0.6 | ∼45 | 110,219,220 |
| V179D | 4.6 | 1.9 | 2.7 | 1.7 | NA | 219 |
| Y181C | 317 | 4.0 | 2.1 | 2.7 | 1.1 | 218–220 |
| Y188L | >42 | 1.1 | 42.6 | 2.8 | >100 | 110,219,220 |
| G190A | 128 | 1.1 | 8.1 | 1.1 | <5 | 218–220 |
| F227C | 17 | 3.6 | 5.1 | 4.1 | >10 | 110,220,221 |
| E138K (of p51) | 1.1 | 2.6 | 2.0 | 2.8 | 1 | 219,220 |
