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Mechanisms underpinning CRS Massive production of TNF alpha and INF gamma by activated T cells activates monocytes and macrophages which in turn produce large amounts of TNF alpha IL-1 and IL-6. These cytokines activate endothelial cells which then increase the production of IL-1 TNF alpha and IL-6 resulting in the production of an autoinflammatory cascade and escalating activation of the coagulation cascade.
