Table 1. Examples of information provided in the product monographs of vaccines.
| Usage warning for patients with anticoagulation | Is SC injection authorized in the product monograph? | |
|---|---|---|
| Pneumococcal vaccine | ||
| Pneumovax | No | Yes |
| Prevenar 13 | Yes | Yes |
| Influenza vaccine | ||
| Vaxigrip Tetra | Yes | Yes |
| Influvac Tetra | Yes | Yes |
| Diphtheria, tetanus, and whooping cough vaccine | ||
| Revaxis | Yes | Yes |
| Varicella-zoster virus | ||
| Zostavax | Yes | Yes |
| COVID-19 vaccines | ||
| Moderna + National Institute of Allergy and Infectious Diseases RNA-based vaccine | Yes, deltoid muscle, needle size not specified | SC not authorized |
| Pfizer/BioNTech + Fosun Pharma RNA-based vaccine | Yes, deltoid muscle, 21-Gauge or narrower | SC not authorized |
| AstraZeneca + University of Oxford viral vector vaccine | Yes, deltoid muscle, needle size not specified | No specified and no adsorbate in the vaccine formulation |
| Sinovac Research and Development Co., Ltd | Yes, exclusion criteria in phase III trial (NCT04456595) deltoid muscle, needle size not specified | No product monograph available, presence of aluminum hydroxide |
| Sinopharm + China National Biotec Group Co + Wuhan Institute of Biological Products | Yes, exclusion criteria in phase III trial (ChiCTR2000034780), injection site not specified, needle size not specified | No product monograph available, presence of aluminum hydroxide |
| CanSino Biological Inc./Beijing Institute of Biotechnology | No, not an exclusion criterion in phase III trial (NCT04691908), deltoid muscle, needle size not specified | No product monograph available |
| Gamaleya Research Institute; Health Ministry of the Russian Federation | No, not an exclusion criterion in phase III trial (NCT04530396), Injection site not specified, needle size not specified | No product monograph available |
| Janssen Pharmaceutical | No, not an exclusion criterion in phase III trial (NCT04505722), injection site not specified, needle size not specified | No product monograph available |
| Novavax | No, not an exclusion criterion in phase III trial (NCT04611802), deltoid muscle, needle size not specified | No product monograph available |
| Anhui Zhifei Longcom Biopharmaceutical + Institute of Microbiology, Chinese Academy of Sciences | Yes, exclusion criteria in phase II trial (NCT04466085), deltoid muscle, needle size not specified | No product monograph available |
| CureVac AG | Yes, exclusion criteria in phase III trial (NCT04674189), deltoid muscle, needle size not specified | No product monograph available |
| Institute of Medical Biology + Chinese Academy of Medical Sciences | Yes, exclusion criteria in the phase III trial (NCT04659239), injection site not specified, needle size not specified | No product monograph available |
| Research Institute for Biological Safety Problems, Rep of Kazakhstan | No, not an exclusion criterion in phase III trial (NCT04691908), injection site not specified, needle size not specified | No product monograph available |
| Bharat Biotech International Limited | No, not an exclusion criterion in phase III trial (NCT04641481), injection site not specified, needle size not specified | No product monograph available, presence of aluminum hydroxide |
Abbreviations: COVID-19, coronavirus disease 2019; RNA, ribonucleic acid; SC, subcutaneous.