Table 1.

Hypophosphatemic diseases caused by FGF23 overproduction and hyperactivity.

Disease	Cause
Autosomal dominant hypophosphatemic rickets/osteomalacia	Dysregulated expression of FGF23 by mutations in the FGF23 gene
Autosomal recessive hypophosphatemic rickets/osteomalacia	Overexpression of FGF23 in bone by mutation in the DMP1 gene
X-linked hypophosphatemic rickets/osteomalacia	Overexpression of FGF23 in bone by mutation in the PEHX gene
McCune-Albright syndrome/fibrous dysplasia	Overexpression of FGF23 in bone
Tumor-induced rickets/osteomalacia	Overexpression of FGF23 in responsible tumors