Skip to main content
. 2021 Mar 10;28(5):265–276. doi: 10.1038/s41434-021-00239-9

Fig. 1. Schematic diagram of the role of CFI in alternative pathway regulation and AAV design.

Fig. 1

A CFI is a key regulator of the alternative pathway and degrades C3b into iC3b and C3dg in the presence of cofactor. Figure adapted with permission from [12]. B Schematic diagram of AAV2 backbone coding sequence. AAV = adeno-associated virus, bGHpA = bovine growth hormone poly adenylation sequence, bp = base pair, C3 = Complement C3, CAG = chicken b-actin promoter with a CMV enhancer and a β-globin intron, CFB = complement factor B, CFD = complement factor D, CFH = complement factor H, CFI = complement factor I, CR1 = Complement Receptor 1, WPRE = Woodchuck hepatitis virus post-transcriptional regulator element. Biorender.com was used to generate Fig. 1A, and B.