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. 2021 Feb 15;28(5):256–264. doi: 10.1038/s41434-021-00219-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — OKR recordings demonstrate significantly decreased visual acuity in eyes of ONC mice treated with AAV2-CAG.eGFP (n = 10; experiments performed in tripicate). Treatment with AAV2- Mice treated with AAV2-CAG.SIRT1 (n = 12; experiments performed in tripicate) show no significant effect on A visual acuity or B RGC survival by day 7. C Representative RGC counts by nuclear BRN3A staining. Data represented as mean ± SEM. *P < 0.05, **P < 0.01 by 1-way ANOVA with Tukey’s HSD post-test.