Table 1.
Prevalence of fall-related side effects of antidepressants
| Orthostatic hypotension | Imbalance and/or dizziness | Extrapyramidal symptoms | Sedation | Delirium or confusional state | Visual impairment | Hyponatremia | |
|---|---|---|---|---|---|---|---|
| SSRIs | |||||||
|
Citalopram Escitalopram Paroxetine Fluvoxamine Fluoxetine Sertraline |
No data No data + + + + + + No data |
+ + + + + + + + + + + + + + + + + + + |
No data No data + + + + No data + + + |
+ + + + + + + + + No data + + + + + + + |
+ + + + + + + + + No data + |
No data + + + + + No data + + + + + + |
+ + + + + + |
| SNRIs | |||||||
|
Venlafaxine Duloxetine |
+ + + + |
+ + + + + + + |
No data + |
+ + + + + + + + |
+ + |
+ + + + + + |
+ + |
| TCAs | |||||||
|
Amitriptyline Nortriptyline Clomipramine Doxepin Maprotiline Dosulepin |
+ + + + + + + + + + + + + + + + + + + |
+ + + + + + + + + + + + + + + + + + + + + + |
No data No data No data + + + No data + + |
+ + + + No data + + + + + + + + + + + + |
+ + + + + + + + + + + + |
+ + + + + + + + + + + + + + + + + + + |
+ + + No data No data + + No data |
| Other | |||||||
|
Mirtazapine Bupropion Trazodone Agomelatine Vortioxetine Mianserin |
+ + + + + + + No data No data + + + |
+ + + + + + + + + + + + + + + + No data |
No data + No data No data No data + |
+ + + + No data + + + + + + No data + + + + |
+ + + + + + + + + + No data No data |
No data + + + + + + + + + No data |
+ No data No data No data + + |
+ : < 1/1000
+ + : 1/100–1/1000
+ + + : 1/10–1/100
+ + + + : > 1/10
Source: antidepressant SmPCs