Table 2.

Model cost inputs

Parameter	Value (in Euros, €)	Source
Medication
Aspirin (100 mg once daily)	1.41a	AIFA
Rivaroxaban (2.5 mg twice daily)	58.52b	AIFA
Health costs
Acute myocardial infarction (0–3 months)	7545	Mantovani et al., 2011 [18]
Post-acute myocardial infarction (3 + months)	980	Mantovani et al., 2011 [18]
Acute stroke (0–3 months)	6164	Lucchese et al., 2017 [19]
Post-acute stroke (3 + months)	1855	Lucchese et al., 2017 [19]
Intracranial hemorrhage	3891	DRG no. 14 [17]
Acute limb ischemia	2199	DRG no. 130, 131 [17]
Minor amputation	6056	DRG no. 114 [17]
Major amputation (0–3 months)	13,948	Marone et al., 2018 [20]
Post-major amputation (3 + months)	4375	Marone et al., 2018 [20]
Major non-fatal extracranial bleed	2091	DRG no. 175 [17]
Venous thromboembolism	2315	DRG no. 128 [17]

AIFA Italian Agency of Medicine, DRG Italian diagnosis-related group tariff

^aPack price (30 tablets) – AIFA

^bPack price (56 tablets) ex-factory plus statutory discounts (− 5%, − 5%)