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. 2021 May 23;9(1):e002076. doi: 10.1136/bmjdrc-2020-002076

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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(A) Heatmap of islet expression of genes in HALLMARK_MYC_TARGETS_V2 with a differential expression between ND and type 1 diabetic subjects in any exocrine region, positive or negative, relative to a threshold of log2(1.2) using a cutoff of FDR<0.70 and the glmTREAT function in edgeR. Color indicates z-score calculated from log2(TMM-CPM normalized counts), as indicated by the color key. (B) Heatmap of islet expression of genes in HALLMARK_ESTROGEN_RESPONSE_EARLY with a differential expression between ND and type 1 diabetic subjects in any exocrine region, positive or negative, relative to a threshold of log2(1.2) using a cutoff of FDR<0.70 and the glmTREAT function in edgeR. Color indicates z-score calculated from log2(TMM-CPM normalized counts), as indicated by the color key. FDR, false discovery rate; ND, non-diabetic subjects; T1D, type 1 diabetic subjects; TMM, trimmed mean of M values.