Figure 6.
MVA on collagen fibers revealed similar structural patterns in murine and human aneurysm tissues
(A) Intensity distribution heatmaps of collagen fibers in human control and ascending thoracic aortic aneurysm (aTAA). Scale bar equals 50 μm.
(B and C) PCA showing a clustering between control and aneurysm in PC-4.
(D and E) MCR decomposed Raman spectra and imaging of murine Cc6 (aneurysm feature, orange) and Cc1 (native collagen feature, red) components applied to human control and TAA tissues indicate a significant difference in the aneurysm-specific signature (Cc6) but not in the native collagen signature (Cc1).
Scale bars equal 5 μm. N = 3, data points are represented as mean score (C) or intensity (E) values ± SD, non-paired t tests were performed; ∗p < 0.05, ∗∗p < 0.01.