Figure 2.

The associations between germline and somatic mutations of DNA damage repair genes with tumor mutation burden (TMB) and neoantigen loads in non-hypermutated cases

(A) Germline and somatic association with TMB.

(B) Germline and somatic associations with SNV neoantigen loads.

(C) Germline and somatic association with indel neoantigen loads. The axes represent the coefficient obtained from the multivariate linear regression analyses.

(D) A schema showing the 13 prioritized DDR genes, which were aggregated into 4 pathways for estimating the combined germline and somatic DDR associations with TMB and neoantigen loads.

(E) The combinatorial germline and somatic DDR associations with TMB and neoantigen loads. The axes represent the coefficients from PLS-PM analysis.

For (A)–(C), and (E), each dot represents a cancer type. Red, blue, orange, and gray represent cancer types in the germline level, somatic level, both levels, and neither level meeting the significance criteria of FDR < 0.05, respectively. The size of the dots represents −log₁₀(FDR), which showed the more significant FDR of either germline or somatic association. The solid gray line indicates equal germline versus somatic associations where the slope = 1.