Table 2.

Body weight and glucose of the experimental animals.

	Wild-type mice		GSDMD−/− mice
	Normal diet	HFD/STZ	Normal diet	HFD/STZ
Body weight (g)	29.2 ± 4.2	22.4 ± 3.2*	29.3 ± 2.0	24.3 ± 3.3*
Glucose (mmol/L)	6.7 ± 0.3	24.1 ± 4.1*	6.1 ± 0.6	24.7 ± 6.4*

Mice were fed a HFD for 4 weeks and then injected with 3 consecutive days of STZ (intraperitoneal at 70 mg/kg) followed by continued HFD feeding for an additional 12 weeks. Values are means ± SEM (n = 6).

HFD high-fat diet, STZ streptozotocin.

*P < 0.05 versus normal-diet mice.