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. 2021 May 25;12:3095. doi: 10.1038/s41467-021-23342-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a An iEEG sample⁴³ and the LNA amplified output. b Noise floor of the headstage LNA and iEEG power spectral density. In the HFO range (80-250 Hz) the noise level of the LNA is below the iEEG noise floor by an order of magnitude. c Frequency response of the implemented filters in the headstage. The band-pass filters are tuned to highlight HFO frequency bands. d ADM circuit simulation response to the ripple-filtered signal. The top plot shows the analog filter output, the middle plot shows the UP spikes generated by the ADM and the bottom plot shows the DN spikes.