Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;7:36. doi: 10.1038/s41421-021-00271-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Higher expression of four meCAF marker genes (PLA2G2A, CRABP2, SERPINE2, and MFAP5) predicting a worse overall survival (OS) in patients with PDAC (TCGA PAAD database, n = 178). b Representative H&E and IHC stainings of meCAF markers (PLA2G2A and CRABP2) indicated high expression of these markers in loose-type PDAC (n = 94). High expression of meCAF markers (PLA2G2A + CRABP2) in the stroma predicted a poor OS in patients with PDAC (n = 76). c Representative IHC staining of myCAF marker (POSTN) indicated its high expression in dense stroma of PDAC (n = 94). The expression level of POSTN in stroma showed no correlation with OS of PDAC patients (n = 76). d–f Representative IHC staining of an iCAF marker (APOD) and CAF subcluster 1 and 2 markers (RGS5 and MYH11). The expression of these markers show no correlation with the overall survival in patients with PDACs. Scale bar, 100 μm. Censored samples are indicated by “+”. Kaplan–Meier curve was used for survival analysis. All statistical analyses were performed with the Log-rank test.