Figure 2.

Oseltamivir affects the susceptibility of immunocompetent mice to A. fumigatus infection

(A) Immunocompetent C57BL/6J mice were treated with PBS (n = 20) or oseltamivir (10 mg/kg) (n = 20) twice daily for 5 consecutive days. On day 3 of treatment, mice were infected intranasally with A. fumigatus or remained uninfected (naive). All mice were sacrificed on days 1 and 3 after infection.

(B) Fungal burden in lung homogenates on days 1 and 3 after infection (log10).

(C) Production of TNF-α, IL-1β, IL-6, and IL-10 was measured from lung homogenates of uninfected (striped bars) or infected (empty bars) mice that were treated with oseltamivir (red bars) or remained untreated (black bars).

(D) The total number of immune cells in lung homogenates from infected or uninfected mice treated with oseltamivir or controls.

(E) Representative histology of the lung tissue sections of the mice on day 1 and day 3 after infection, stained with H&E.

Data are presented as mean ± SEM. ∗∗∗p < 0.001, ∗∗p < 0.01, ∗p < 0.05.