REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
BV510 CD45	BioLegend	RRID:AB_2561392
PerCp-Cy5.5 Ly-6C	BioLegend	RRID:AB_1727558
BV785 Ly-6G	BioLegend	RRID:AB_2566317
BV605 CD11c	BioLegend	RRID:AB_2562415
PE-Cy7 CD11b	BioLegend	RRID:AB_2033994
FITC I-A/I-E	BioLegend	RRID:AB_313321
Alexa Fluor 647 CD103	BioLegend	121410
APC F4/80	BioLegend	RRID:AB_893481
PE Siglec F	BD-Pharmigen	552126
CellROX™ Green Reagent	Thermo Fisher Scientific	C10444
Goat anti-Human IgG (H+L) Secondary Antibody, Alexa Fluor 647	Thermo Fisher Scientific	RRID:AB_2535862
Fungal strains
Aspergillus fumigatus V05-27	Isolated from patient	N/A
Aspergillus fumigatus VP145_12	Isolated from patient	N/A
Chemicals, peptides, and recombinant Proteins
Recombinant human SIGLEC15-Fc	Bio-Techne	9227-SL-050
Phosphate Buffered Saline (PBS)	Thermo Fisher Scientific	10010056
Tween-20	Sigma-Aldrich	P1379
Sabouraud Glucose Agar with Chloramphenicol	Sigma-Aldrich	89579
Neuraminidase from Clostridium perfringens	Sigma	N2876-6UN
RPMI 1640	Life Technologies	22409031
Gentamycin	Centraform	N/A
Pyruvate	Invitrogen	11360
Ficoll-Paque Plus	GE Healthcare	17-1440-03
Bovine Serum Albumin (BSA)	Sigma	A7030
iScript cDNA synthesis kit	Bio-Rad	1708891
Power SYBR Green	4368708	Life Technologies
Luminol (3-amino-2,3, dihydro-1,4-phtalazinedione)	Sigma	A8511-5G
Zymosan	Sigma	Z4250-1G
Oseltamivir carboxylate	Bioconnect Life Sciences	N/A
Lipofectamine RNAiMAX Transfection reagent	Fisher Scientific	10514953
Ketamidor	Mitcher Pharm	N/A
Medetomidine (Dormtor®)	Ecuphar	N/A
Cortisone-21 acetate	Acros Organics	448960250
Baytril®	Bayer	N/A
Cyclophosphamide
Oseltamivir (Tamiflu®)	Roche	N/A
DMEM medium	Thermo Fisher Scientific	10938025
Penicillin/Streptomycin	Thermo Fisher Scientific	15140122
HEPES Buffer Solution	Thermo Fisher Scientific	15630056
Fetal Bovine Serum	Thermo Fisher Scientific	10500056
Collagenase D	Sigma-Aldrich	11088858001
Bovine Serum Albumin (BSA)	Sigma-Aldrich	A7906
Formalin	Sigma-Aldrich	HT501128
Percoll	GE Healthcare	17089102
L-glutamine	Sigma-Aldrich	25030081
Critical commercial assays
Human TNF-α ELISA	Bio-Techne/R&D	DY201
Human IL-1β ELISA	Bio-Techne/R&D	DY201
Human IL-8 ELISA	IBL International	M9318
Mouse TNF-α ELISA	BioLegend	430904
Mouse IL-1β ELISA	BioLegend	432604
Mouse IL-6 ELISA	BioLegend	431304
Experimental Models: Organisms/strains
C57BL/6 mice, 8 weeks old, adult male	Jackson Laboratory	N/A
BALB/c mice, 10-weeks old, adult male	Janvier, Le Genest, France	N/A
Oligonucleotides
ON-Target plus human SIGLEC15 siRNA smartpool (Dharmacon)	GE Healthcare	L-023427-02-0005
ON-Target plus non-targeting pool siRNA	GE Healthcare	D-001810-10-05
Forward primer hSIGLEC15: 5′-CGCG GATCGTCAACATCTC-3′	Biolegio (Primers designed by BLAST)	N/A
Reverse primer hSIGLEC15: 5′-GTTCG GCGGTCACTAGGTG-3′	Biolegio (Primers designed by BLAST)	N/A
Forward primer hRPL37: 5′-ATTGAA ATCAGCCAGCACG-3′	Biolegio (Primers designed by BLAST)	N/A
Reverse primer hRPL37: 5′- AGGAAC CACAGTGCCAGAT-3′	Biolegio (Primers designed by BLAST)	N/A
Deposited data
RNA seq	NCBI database	GSE162746
Software and algorithms
GraphPad Prism 5.0	Graphpad Software	https://www.graphpad.com
Kaluza	Beckman Coulter	N/A
FlowJo	Tree Star Inc	N/A
ImageJ software v1.50i	NHI	N/A