Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Simulation modeling data showing percent of patients reaching PK (10 μg/mL) and PD targets (17% maximum lysis) 30 and 60 minutes after infusion start.
| Dose (mg) | PK after 30 minutes | PD after 30 minutes | PK after 60 minutes | PD after 60 minutes |
|---|---|---|---|---|
| 300 | 77% | 70% | 13% | 23% |
| 350 | 93% | 73% | 30% | 50% |
| 400 | 100% | 87% | 43% | 60% |
| 450 | 100% | 83% | 63% | 67% |
| 500 | 100% | 90% | 83% | 77% |
| 550 | 100% | 90% | 93% | 83% |
| 600 | 100% | 90% | 97% | 87% |
| 650 | 100% | 90% | 100% | 87% |
| 700 | 100% | 90% | 100% | 90% |
| 750 | 100% | 93% | 100% | 90% |
| 800 | 100% | 100% | 100% | 90% |
