. 2021 Jan 9;29(1):23–38. doi: 10.1007/s40199-020-00378-1

Table 1.

The protective effect of compounds 9–20 against H₂O₂-induced injury in PC12 cell line at different concentrations

Compound	n	R	PC12 cells viability (% of control)^a
Compound	n	R	H₂O₂	1 μM	5 μM	10 μM	20 μM	50 μM
9	3	H	22.2 ± 2.1	28.1 ± 1.6^***	32.4 ± 2.6^***	36.0 ± 1.8^***	37.2 ± 1.5^***	38.5 ± 1.7^***
10	3	6-Br	20.1 ± 1.2	31.3 ± 1.0^***	33.5 ± 0.9^***	40.5 ± 0.9^***	43.8 ± 1.0^***	48.1 ± 1.1^***
11	4	H	25.0 ± 1.4	33.0 ± 1.2^***	39.3 ± 0.8^***	41.3 ± 1.2^***	44.2 ± 0.8^***	46..5 ± 1.2^***
12	4	6-Br	26.6 ± 0.5	38.3 ± 1.0^***	48.9 ± 1.2^***	52.8 ± 0.5^***	59.3 ± 0.6^***	64.3 ± 1.4^***
13	4	7-F	24.7 ± 1.4	37.2 ± 0.6^***	41.0 ± 1.0^***	48.3 ± 2.0^***	53.0 ± 2.6^***	59.7 ± 2.2^***
14	4	6-Cl	24.6 ± 0.2	38.8 ± 0.8^***	44.7 ± 0.5^***	50.5 ± 0.6^***	60.9 ± 0.6^***	66.4 ± 1.0^***
15	5	H	25.8 ± 1.1	44.9 ± 1.2^***	52.0 ± 1.1^***	57.2 ± 0.7^***	61.6 ± 1.1^***	65.2 ± 0.2^***
16	5	6-Br	25.9 ± 1.3	47.7 ± 1.0^***	59.0 ± 0.8^***	67.8 ± 0.6^***	71.6 ± 1.6^***	81.8 ± 1.2^***
17	5	6-Cl	25.9 ± 0.9	44.9 ± 0.6^***	52.8 ± 0.7^***	60.8 ± 1.1^***	69.3 ± 0.7^***	75.3 ± 1.4^***
18	3	–	22.8 ± 1.2	28.3 ± 0.9^***	31.0 ± 2.1^***	36.7 ± 1.1^***	40.1 ± 0.9^***	43.4 ± 0.5^***
19	4	–	27.5 ± 1.0	35.6 ± 0.3^***	42.8 ± 0.7^***	45.4 ± 1.2^***	50.2 ± 0.6^***	53.9 ± 0.1^***
20	5	–	28.0 ± 0.4	41.0 ± 0.3^***	47.2 ± 0.5^***	52.3 ± 0.5^***	57.4 ± 0.5^***	62.5 ± 0.8^***
Quercetin	–	–	28.6 ± 0.8	40.7 ± 0.4^***	47.3 ± 0.9^***	53.7 ± 1.2^***	56.9 ± 0.5^***	58.8 ± 0.1^***

^a)***Cell viability was determined using MTT assay protocol. Data are expressed as the mean ± SEM of three independent replicates. The significant (p < 0.001) values with respect to the H₂O₂ group