Table 2.
Inhibitory activity of the synthesized compounds 9–20 against AChE and BuChE
| Compound | n | R | AChEa IC50 (μM) | BuChEa IC50 (μM) |
|---|---|---|---|---|
| 9 | 3 | H | >100 | >100 |
| 10 | 3 | 6-Br | >100 | >100 |
| 11 | 4 | H | >100 | >100 |
| 12 | 4 | 6-Br | >100 | >100 |
| 13 | 4 | 7-F | 56.50 ± 3.91 | >100 |
| 14 | 4 | 6-Cl | >100 | >100 |
| 15 | 5 | H | >100 | >100 |
| 16 | 5 | 6-Br | >100 | >100 |
| 17 | 5 | 6-Cl | >100 | >100 |
| 18 | 3 | – | >100 | 15.32 ± 1.21 |
| 19 | 4 | – | >100 | 7.55 ± 0.78 |
| 20 | 5 | – | >100 | >100 |
| Donepezil | – | – | 0.027 ± 0.004 | 4.01 ± 0.56 |
aInhibitor concentration (mean ± SEM of three experiments) required for 50% inactivation of ChE