Table 2.

The effects of combination therapy amoxicillin, clarithromycin and/or omeprazole on ulcer formation in Induced P-gp rats

No	Treatment/ Group	Parameters
		Organ index	Gastric pH	Ulcer surface area (cm2)	Ulcer index	% ulcer healing
1	Normal control (Healthy, no treatment)	0.007 ± 0.0008	5.33 ± 1.6	0	0	0
2	Vehicle control group	0.007 ± 0.0008	5.32 ± 1.0	0.0187 ± 0.03	3.50 ± 0.18	0
3	Positive control group	0.007 ± 0.001	4.68 ± 1.0	0.0033 ± 0.008	1.77 ± 0.13###	82%
4	AB group	0.007 ± 0.0004	5.07 ± 0.47	0.0050 ± 0.01	1.79 ± 0.19###	73%
5	PPI group	0.007 ± 0.0005	5.26 ± 1.33	0.0067 ± 0.012	3.48 ± 0.21	64%

Positive control (standard regimen) group treated with 90 mg/kg amoxicillin, 135 mg/kg clarithromycin, 3.6 mg/kg omeprazole. AB group treated by amoxicillin + clarithromycin; PPI group treated by omeprazole; Vehicle used is 0.25% carboxymethylcellulose. Value are mean ± standard error mean of six animals in each group. All comparisons were performed using one-way ANOVA (dunnet’s test). *** p < 0.001, ** p < 0.01 and *p < 0.05 vs normal control rats. ### p < 0.001, ## p < 0.01 and # p < 0.05 vs vehicle control rats