TABLE 4.
The annotated efflux pumps in Francisella species and subspecies.
| Francisella tularensis subsp. tularensis Schu S4 | Francisella tularensis subsp. holarctica LVS | Francisella tularensis subsp. novicida U112 | |
| Locus (KEGG orthology, Uniprot) name [E.C. number], other information | Locus (KEGG orthology, Uniprot) name [E.C. number], other information | Locus (KEGG orthology, Uniprot) name [E.C. number], other information | |
| Outer membrane efflux proteins | |||
| TolC (OMP), outer membrane efflux protein, tolC precursor | FTT_1724c (K12340) | FTL_1865 (K12340) | FTN_1703 (K12340, A0Q8J5) |
| AcrAB system | |||
| AcrA, efflux transporter, RND family, MFP subunit. MexH family. (Also annotated as a Co/Zn/Cd efflux system membrane fusion protein in some strains) | FTT_0106c (K03585) | FTL_1671 (K03585) | FTN_1609 (K03585, A0Q8A4), RND family efflux transporter, MFP subunit. MexAB-OprM [MD:M00718] |
| AcrB (RND) | FTT_0105c transporter AcrB/AcrD/AcrF family | FTL_1672 (Bina et al., 2008) | FTN_1610 (K18138, A0Q8A5) AcrB/AcrD/AcrF family |
| FtlC | FTT_1095c | FTL_1107 | FTN_0779 |
| Emr MFS-type multidrug efflux pump (EMR locus) (Alqahtani et al., 2018) | |||
| SilC | FTT_1258 | FTL_0686 (Alqahtani et al., 2018) | FTN_1277 |
| EmrA1, outer membrane efflux protein, | FTT_1257 (K03543) | FTL_0687 (K03543) (Alqahtani et al., 2018) | FTN_1276 (K03543) |
| EmrB, membrane fusion protein, multidrug efflux system membrane fusion protein; membrane fusion component of tripartite multidrug resistance system | FTT_1256 (K03446) | FTL_0688 (K03446) (Alqahtani et al., 2018) | FTN_1275 (K03446) |
| Other efflux systems | |||
| Efflux transporter, RND family, MFP subunit. | FTT_0747c, hypothetical protein (261 aa), HlyD_D23 domain | FTL_1366 (partial, 105 aa) | FTN_0718 (Uniprot A0Q5U5), (285 aa), membrane fusion protein |
| ErmE multidrug resistance antiporter of cations and cationic drugs, small multidrug resistance family proteins | FTN_0799 | ||
| ArsB (arsenite-antimonite efflux family protein) | FTT_0853 | Not found | FTN_0382 (A0Q4X0) FTN_0800 |
| ArsR family transcriptional regulator K03892, arsenate/arsenite/antimonite-responsive transcriptional repressor (Xu et al., 1996) | FTT_0868c | FTL_0370 | FTN_0395 FTN_0801 |