TABLE 6.
Putative polymyxin resistance genes in Francisella (selected data from Uniprot.org and Kegg.jp).
| Locus (gene) names | Organism | UniProt entry | Phenotype | Protein names | Length | References |
| LpxF type | ||||||
| FTN_0295 (lpxF ) | Francisella tularensis subsp. novicida (strain U112) | A0Q4N6 | Polymyxin Sensitivity | Lipid A 4’-phosphatase | 222 | Wang et al., 2007 |
| FTT_1634c | Francisella tularensis subsp. tularensis (strain SCHU S4) | Q5NEJ5 | Hypothetical Protein | 222 | ||
| FTL_1704 | Francisella tularensis subsp. holarctica LVS | Q2A1R7 | Hypothetical Membrane Protein | 222 | ||
| ArnT type | ||||||
| FN3523_1260 | Francisella hispaniensis | AEE26563 | Polymyxin resistance protein ArnT, undecaprenyl phosphate-alpha-L-Ara4N transferase Melittin resistance protein PqaB | 587 | ||
| FTT_0455c | Francisella tularensis subsp. tularensis SCHU S4 | Q5NHJ9 (YP_169493) | Dolichyl-phosphate-mannose-protein mannosyltransferase family protein | 587 | Phillips et al., 2004 | |
| FTN_0546 | Francisella tularensis subsp. novicida (strain U112) | A0Q5C6 | Dolichyl-phosphate-mannose-protein mannosyltransferase family protein | 587 | ||
| FTL_1609 | Francisella tularensis subsp. holarctica LVS | CAJ80048 | Dolichyl-phosphate-mannose-protein mannosyltransferase family protein | 586 | ||
| ArnC Type | ||||||
| FN3523_1261 | Francisella hispaniensis | F4BGH0 | Polymyxin resistance protein ArnC, glycosyl transferase | 317 | ||
| FTT_0454 (yfdH) | Francisella tularensis subsp. tularensis (strain SCHU S4) | Q5NHK0 | Glycosyl transferase, group 2 family protein | 318 | ||
| FTN_0545 | Francisella tularensis subsp. novicida (strain U112) | A0Q5C5 | Glycosyl transferase, group 2 | 318 | ||
| FTL_1611 | Francisella tularensis subsp. holarctica LVS | A0A0B6E7W3 (CAJ80050) | Glycosyl transferase, group 2 family protein | 317 | ||
At least three categories of Francisella genes have “polymyxin resistance” terms associated with them: lpxF, arnC, and arnT genes.