TABLE 4.
Differentially methylated positions in candidate genes identified in three NSCLP twin pairs.
| MZ pair | Gene | Chr | Position | Delta methylation | Genomic feature* | Distance to TSS (kb)# | Candidate group& |
| MZ1 | TP63 | 3 | 189509045 | 0.80 | In (alt. promoter) | 1.6 | AGV |
| WNT7A | 3 | 13787881 | −0.78 | IGR | 133 | AGV | |
| MAFB | 20 | 39373248 | −0.84 | IGR | −55 | AGV | |
| GDF6 | 8 | 96365815 | 0.85 | IGR | 807 | AGV | |
| MZ2 | MAF | 16 | 79211133 | 0.63 | IGR | 400 | AGV |
| FBN1 | 15 | 48849784 | −0.78 | In | 88 | SCLP | |
| MZ6 | SOX9 | 17 | 71010900 | −0.59 | IGR | 890 | SCLP |
*In, Intron; IGR, intergenic region; #TSS, transcriptional start site; Genome assembly, GRCh37/hg19; &AGV, associated genetic variant; SCLP, syndromic cleft lip and palate.