TABLE 7.

Pathways enriched for differentially methylated genes*.

Index	Name	Adjusted p-value
MZ1
1	Signaling pathways regulating pluripotency of stem cells	0.009879
2	Thyroid hormone signaling pathway	0.01003
3	Longevity regulating pathway	0.0102
4	Transcriptional misregulation in cancer	0.01558
5	Small cell lung cancer	0.01709
6	Hippo signaling pathway	0.02574
7	Longevity regulating pathway	0.0261
MZ3
1	Wnt signaling pathway	0.0008854
2	Melanogenesis	0.001263
3	Pathways in cancer	0.001309
4	Insulin secretion	0.00152
5	Glucagon signaling pathway	0.002417
6	Pancreatic secretion	0.002557
7	Cushing syndrome	0.002559
8	Basal cell carcinoma	0.002761
9	Salivary secretion	0.01002
10	cAMP signaling pathway	0.01172
11	Aldosterone synthesis and secretion	0.01216
12	Gastric cancer	0.01276
13	Hippo signaling pathway	0.01431
14	Gastric acid secretion	0.02412
15	Thyroid hormone synthesis	0.02429
16	Oocyte meiosis	0.02514
17	Relaxin signaling pathway	0.02519
18	Vascular smooth muscle contraction	0.02559
19	Cell cycle	0.02588
20	p53 signaling pathway	0.02664
21	Estrogen signaling pathway	0.02739
22	Signaling pathways regulating pluripotency of stem cells	0.02791
23	Apelin signaling pathway	0.0287
24	Colorectal cancer	0.02993
25	Adrenergic signaling in cardiomyocytes	0.03086
MZ8
1	Hippo signaling pathway	0.03994

*No significant enrichment in any Kegg pathways was identified in MZ2, MZ6, and MZ7.