Skip to main content
. 2021 May 12;8:653336. doi: 10.3389/fcvm.2021.653336

Table 2.

Medical therapy in heart failure.

ACEI ARB Beta-blocker MRA ARNI SGLT2I Diuretic
HFrEF ↑↑ ↑↑ ↑↑ ↑↑ ↑↑ ↑↑ ?
HFmrEF ? ? ?
HFpEF × × ? ?

↑↑: Proven cardiovascular benefit.

↑: Potential cardiovascular benefit.

×: No cardiovascular benefit.

?: Uncertain cardiovascular benefit.

ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blocker; MRA, mineralocorticoid receptor antagonist; ARNI, angiotensin receptor—neprilysin inhibitor; SGLT2I, sodium glucose cotransporter 2 inhibitors.