Table 1.

Overview of the studies included in the meta-analysis.

References	Methods for determining the infarct size	Sample size (n)	Melatonin administration	Reperfusion medical strategies	Target disease	Effect	Risk of bias
Gögenur et al. (15)	Levels of troponin I	50	Melatonin orally and intraoperatively	CABG	Elective abdominal aortic aneurysm repair	CP	High
Ghaeli et al. (16)	Levels of troponin T	40	Melatonin orally	PCI	AMI	No effect	High
Dwaich et al. (17)	LVEF, levels of troponin I	45	Melatonin orally	CABG	CABG	CP	Low
Ekeloef et al. (18)	Levels of troponin T, LVEF, and CRM	48	IV and IC melatonin	PCI	AMI	No effect	Low
Dominguez-Rodriguez et al. (19)	Levels of troponin I, LVEF, and CRM	125	IV and IC melatonin	PCI	AMI	CP in the first tertile (early after symptom onset)	Low
Shafiei et al. (20)	LVEF	88	Melatonin orally	CABG	CABG	CP	Low

AMI, acute myocardial infarction; CABG, coronary artery bypass grafting; CP, cardioprotection; CRM, cardiovascular magnetic resonance; IC, intracoronary; IV, intravenous; LVEF, left ventricular ejection fraction; PCI; percutaneous coronary intervention.