Table 3.
Multivariate analysis of factors associated with overall survival in the osteosarcoma cohort with inclusion of IMPDH2 expression.
| Factor | Overall survival | |
|---|---|---|
| HR (95% CI) | P value | |
| Age at diagnosis (years) | ||
| ≤ 15 | 1.00 | – |
| > 15 | 1.30 (0.80–2.11) | 0.289 |
| Site | ||
| Extremities | 1.00 | – |
| Axial | 1.04 (0.49–2.20) | 0.915 |
| Stage | ||
| IIB | 1.00 | – |
| III | 2.43 (1.48–3.99) | < 0.001 |
| Treatment completion | ||
| Completed | 1.00 | – |
| Not completed | 3.10 (1.89–5.08) | < 0.001 |
| IMPDH2 expression | ||
| Low (IRS ≤ 8) | 1.00 | – |
| High (IRS > 8) | 1.40 (0.87–2.27) | 0.169 |