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Multivariate analysis of factors associated with overall survival in the osteosarcoma cohort with inclusion of HPRT expression.
| Factor | Overall survival | |
|---|---|---|
| HR (95% CI) | P value | |
| Age at diagnosis (years) | ||
| ≤ 15 | 1.00 | – |
| > 15 | 1.30 (0.80–2.12) | 0.286 |
| Site | ||
| Extremities | 1.00 | – |
| Axial | 1.14 (0.53–2.48) | 0.736 |
| Stage | ||
| IIB | 1.00 | – |
| III | 2.38 (1.44–3.91) | 0.001 |
| Treatment completion | ||
| Completed | 1.00 | – |
| Not completed | 3.20 (1.94–5.27) | < 0.001 |
| HPRT expression | ||
| High (IRS > 2) | 1.00 | – |
| Low (IRS ≤ 2) | 1.70 (1.01–2.84) | 0.044 |
