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Multivariate analysis of metastasis-free survival in osteosarcoma patients and IMPDH2 expression in post-chemotherapy tissues (n = 20).
| Factor | Overall survival | |
|---|---|---|
| HR (95% CI) | P value | |
| Age at diagnosis (years) | ||
| ≤ 15 | 1.00 | – |
| > 15 | 0.66 (0.15–2.84) | 0.576 |
| Gender | ||
| Male | 1.00 | – |
| Female | 0.21 (0.05–0.88) | 0.033 |
| Site | ||
| Extremities | 1.00 | – |
| Axial | 0.71 (0.14–3.73) | 0.687 |
| IMPDH2 expression | ||
| Low (IRS ≤ 6) | 1.00 | – |
| High (IRS > 6) | 7.42 (1.22–45.06) | 0.030 |
