Table 2.
Calculated ratios for prion diseases, Alzheimer’s disease (AD), frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), frontotemporal lobar degeneration with tau inclusions (FTLD-tau), and dementia with Lewy bodies (DLB).
| Ratios | Prion diseases | AD | FTLD-TDP | FTLD-tau | DLB | p-value |
|---|---|---|---|---|---|---|
| TDP-43/PGRN | 0.874 (0.584–1.702) | 2.376 (1.301–2.818) | 1.151 (0.696–1.764) | 0.908 (0.607–1.757) | 1.365 (0.933–2.417) | < 0.0001 |
| TDP-43/Aβ42 | 4.475 (3.508–6.714) | 17.349 (11.584–32.790) | 11.787 (5.925–14.510) | 8.812 (4.589–10.407) | 5.388 (4.393–10.961) | < 0.0001 |
| TDP-43/p-tau | 68.7 (42.6–104.1) | 131.1 (82.5–171.0) | 135.8 (87.99–202.80) | 139.7 (73.5–193.0) | 105.7 (83.29–152.50) | = 0.0006 |
| TDP-43/t-tau | 2.74 (1.89–3.46) | 18.23 (9.20–26.74) | 13.31 (4.92–25.62) | 28.42 (14.99–35.32) | 16.95 (11.78–25.62) | < 0.0001 |
| TDP-43/NfL | 0.210 (0.147–0.313) | 2.368 (1.445–3.344) | 0.610 (0.366–1.325) | 1.264 (0.830–1.618) | 2.155 (0.806–3.515) | < 0.0001 |
| PGRN/ Aβ42 | 5.879 (3.739–7.429) | 10.937 (6.870–13.978) | 6.866 (5.114–17.181) | 7.969 (4.881–9.929) | 4.352 (3.494–5.810) | = 0.0002 |
| PGRN/ p-tau | 85.07 (49.41–123.27) | 55.57 (42.76–91.33) | 113.24 (85.52–161.65) | 132.77 (94.20–166.47) | 81.67 (48.89–96.43) | = 0.0017 |
| PGRN/ t-tau | 3.28 (1.61–4.31) | 7.71 (5.10–12.24) | 9.38 (6.30–19.33) | 21.89 (14.76–35.27) | 13.14 (7.24–15.95) | < 0.0001 |
| PGRN/NfL | 0.249 (0.122–0.400) | 1.193 (0.747–1.736) | 1.036 (0.264–1.703) | 1.064 (0.758–2.435) | 1.335 (0.901–1.574) | < 0.0001 |
| NfL/Aβ42 | 20.144 (13.331–43.573) | 7.729 (4.956–21.135) | 11.760 (5.670–28.921) | 6.968 (3.522–11.780) | 3.252 (1.910–5.852) | < 0.0001 |
| NfL/p-tau | 335.82 (226.98–455.91) | 47.89 (29.87–99.27) | 245.03 (43.06–469.79) | 132.29 (61.49–192.27) | 48.49 (32.56–78.46) | < 0.0001 |
| NfL/t-tau | 13.29 (6.88–21.24) | 6.52 (4.43–15.89) | 25.87 (6.30–52.42) | 15.60 (10.02–33.22) | 6.46 (4.60–13.30) | = 0.0225 |
| t-tau/p-tau | 24.49 (15.38–39.68) | 7.08 (5.34–9.33) | 11.69 (7.44–14.04) | 6.78 (4.25–8.99) | 6.90 (6.29–7.21) | < 0.0001 |
| t-tau/Aβ42 | 1.828 (1.389–2.548) | 1.273 (0.658–2.132) | 0.718 (0.381–1.410) | 0.369 (0.282–0.544) | 0.360 (0.252–0.603) | < 0.0001 |
| p-tau/Aβ42 | 0.072 (0.048–0.106) | 0.166 (0.108–0.245) | 0.065 (0.047–0.095) | 0.060 (0.053–0.065) | 0.050 (0.041–0.091) | < 0.0001 |
Results are shown as medians with the interquartile range. P-values represent the approximate two-tailed p-values of the Kruskal–Wallis test when comparing all groups (p < 0.05). TAR DNA binding protein (TDP)-43; progranulin (PGRN); neurofilament light chain (NfL); total-tau (t-tau); phosphorylated-tau (181P) (p-tau); amyloid-beta (1–42) (Aβ42).