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. 2021 May 25;8:138. doi: 10.1038/s41597-021-00923-w

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© The Author(s) 2021

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Fig. 4 — T₁-weighted MPRAGE with an isotropic resolution of 250 µm based on eight repetitions. (a) Originally published version¹ registered using a linear interpolator. (b) As before, but registered using a BSpline interpolator. The resulting image is much sharper, however, visually signal to noise ratio is considerably reduced. (c) Updated version based on the same raw data³, after application of a method to denoise during reconstruction²⁷ and registration using a Bspline interpolator. Visually, in comparison to (a) the resulting image is much sharper while the overall image quality in terms of noise appears equal. The images are windowed identically.