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. 2021 May 12;9:658088. doi: 10.3389/fcell.2021.658088

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Copyright © 2021 Gao and Pu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of differentiation of hPSCs into cardiac progenitor cells. (A) MESP1⁺ cells were obtained after treatment of GSK3 inhibition and then were cultured in four different conditions: (a) suspension culture of spheroids, (b) adherent culture of spheroids on gelatin, (c) adherent culture of single cells on gelatin, and (d) adherent culture of single cells on Matrigel. (B) Isoxazole (ISX-9), a cardiogenic small molecule, induced CPCs from hPSCs, which further differentiated into three cardiac lineages in vitro.