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. 2021 May 12;12:641420. doi: 10.3389/fpls.2021.641420

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Copyright © 2021 Reyes-Barrera, Soria-Guerra, López-Martínez, Huerta, Salinas-Jazmín, Cabello-Gutiérrez and Alpuche-Solís.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EB blocks the binding of viral hemagglutinin to its receptor. EB expressed in microalgae and synthetic EB inhibited the viral hemagglutination. Dose-response curves of each peptide show the ability of EB to prevent viral hemagglutinin binding to sialic acid in red blood cell membrane. (A) EB inhibitory effects vs. influenza pdm A/H1N1 strain. (B) EB inhibitory effects vs. influenza A H1N1 Virginia/ATTC/2009 strain. The graph shows the mean hemagglutination inhibition in percentage for each EB ± SD. The results belong to three independent assays. (MQ): Milli Q water extracts; (TRIS): Tris Buffer extracts.